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In this randomized, double-blind trial we tested whether on-demand H-antihistamine desloratadine in standard and higher doses is able to improve the resolution of existing wheals.Symptoms of 29 patients with chronic spontaneous urticaria were followed without treat­ment on one day and again on another day during the next 3 weeks after a single dose of either 5 mg or 20 mg desloratadine, using different objective measures.They inhibit the peripheral and central H1 receptors and have a higher affinity for muscarinic, alpha adrenergic and serotingeric (5-HT) receptors.

Advances in pharmacology have permitted more specific targeting of receptors, and greater selectivity of agents, which necessitates greater precision when describing these agents and their effects: Doctors often administer sedatives to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures.E-mail: [email protected] spontaneous urticaria (CSU) is one of the most frequent skin disorders.It is characterized by a recurrent and spontaneous appearance of itchy wheals with or without angioedema, for 6 weeks or longer (1, 2).While the intervention with both doses of desloratadine was effective in terms of a reduction in hyperthermic skin area, there was no improvement in wheal area and wheal volume compared with no treatment.Wheal numbers were reduced after treatment with 20 mg, but not 5 mg, desloratadine.

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