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is intricately regulated by a number of factors including extracellular matrix, growth factors, membrane-bound proteinases, and integrins (3, 4).Apoptotic endothelial cells stained strongly for cleaved caspase-3, and terminal d UTP nick-end labeling staining revealed fragmented nuclei in vinblastine-treated but not control angiogenic areas.Together, these findings indicate that microtubule-depolymerizing agents directly induce endothelial network collapse leading to endothelial cell apoptosis in a manner dependent on the small GTPase, Rho A.Special attention in the process of fabrication is in the choice of parts that are assembled in NAT audio components. When ever it is possible, New Old Stock (NOS) tubes of the worlds most famous manufacturers (General Electric, RCA, CEI Electron Tube, EI) are implemented. NAT Audio was show up at an exhibition Praha audio Show, wich took plase on Friday, March 31 and Saturday, April 1 at the hotel Don Giovanni in Prague. Our distributor KRAUTWIRE beside theirs best models presented also NAT AUDIO units.